Wearable sensing technology is an essential link to future personalized medicine. However, to obtain a complete picture of human health, it is necessary but challenging to track multiple analytes inside the body simultaneously. Here, we present a wearable plasmonic-electronic sensor with “universal” molecular recognition ability. Flexible plasmonic metasurface with surface-enhanced Raman scattering (SERS)–activity is introduced as the fundamental sensing component in a wearable sensor since we solved the technical challenge of maintaining the plasmonic activities of their brittle nanostructures under various deformations. Together with a flexible electronic sweat extraction system, our sensor can noninvasively extract and “fingerprint” analytes inside the body based on their unique SERS spectra. As a proof-of-concept example, we successfully monitored the variation of trace-amounts drugs inside the body and obtained an individual’s drug metabolic profile. Our sensor bridges the existing gap in wearable sensing technology by providing a universal, sensitive molecular tracking means to assess human health.
Read full text: Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces. YINGLI WANG, CHEN ZHAO, JINGJING WANG, XUAN LUO, LIJUAN XIE, SHIJIE ZHAN, JONGMIN KIM, XIAOZHI WANG, XIANGJIANG LIU, YIBIN YING, SCIENCE ADVANCES, 22 JAN 2021 : EABE4553